Zac Varghese Selected Research

Caseins (Casein)

1/2016	Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.
10/2015	Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.
5/2015	Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice.
1/2014	Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway.
12/2013	Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet.
5/2012	Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export.
10/2011	Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice.
6/2011	Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice.
5/2011	Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis.
9/2008	Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Zac Varghese Research Topics

Disease

21	Inflammation (Inflammations) 01/2020 - 01/2003
7	Non-alcoholic Fatty Liver Disease 05/2015 - 09/2008
6	Atherosclerosis 01/2021 - 10/2002
5	Hepatoblastoma 04/2014 - 09/2008
4	Chronic Renal Insufficiency 01/2021 - 12/2009
4	Fibrosis (Cirrhosis) 12/2017 - 10/2011
4	Insulin Resistance 10/2015 - 06/2011
4	Hyperlipidemias (Hyperlipidemia) 05/2015 - 07/2005
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 02/2014
3	Obesity 03/2019 - 12/2005
3	Neoplasms (Cancer) 03/2019 - 12/2005
3	Fatty Liver 01/2019 - 04/2012
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2019 - 12/2018
2	Hyperglycemia 10/2015 - 12/2013
2	Vascular System Injuries 12/2009 - 08/2008
2	Chronic Kidney Failure (Chronic Renal Failure) 08/2008 - 10/2002
1	Hepatocellular Carcinoma (Hepatoma) 03/2022
1	Hypercholesterolemia 03/2022
1	Hyperphosphatemia 01/2021
1	Uremia 01/2021
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Neoplasm Metastasis (Metastasis) 12/2018
1	Carcinogenesis 12/2018
1	Alcoholic Fatty Liver 01/2018
1	Platelet Glycoprotein IV Deficiency 01/2017
1	Glucose Intolerance 10/2015
1	Necrosis 01/2014
1	Weight Gain 12/2013
1	Hyperinsulinism (Hyperinsulinemia) 04/2012
1	Hypertriglyceridemia 04/2012
1	Infections 04/2012
1	Kidney Diseases (Kidney Disease) 10/2011
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2011
1	Proteinuria 12/2009
1	Dyslipidemias (Dyslipidemia) 10/2007
1	Metabolic Diseases (Metabolic Disease) 12/2005
1	Infertility (Sterility) 12/2005
1	Hypertrophy 12/2005
1	Hypertension (High Blood Pressure) 12/2005

Drug/Important Bio-Agent (IBA)

18	LipidsIBA 01/2019 - 01/2003
13	CholesterolIBA 03/2022 - 07/2005
10	Caseins (Casein)FDA Link 01/2016 - 09/2008
7	Fatty Acids (Saturated Fatty Acids)IBA 12/2018 - 01/2014
5	Sirolimus (Rapamycin)FDA Link 10/2015 - 07/2005
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2016
3	CytokinesIBA 05/2015 - 04/2012
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2014 - 09/2007
3	Interleukin-6 (Interleukin 6)IBA 01/2014 - 05/2011
3	ApolipoproteinsIBA 10/2011 - 07/2005
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 09/2008
2	Olive OilIBA 03/2019 - 12/2018
2	Apolipoproteins E (ApoE)IBA 01/2019 - 10/2011
2	Nonesterified Fatty Acids (NEFA)IBA 01/2018 - 06/2011
2	Advanced Glycation End ProductsIBA 12/2017 - 07/2011
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 05/2015
2	Scavenger Receptors (Scavenger Receptor)IBA 12/2017 - 10/2011
2	TOR Serine-Threonine KinasesIBA 10/2015 - 04/2014
2	Insulin (Novolin)FDA Link 10/2015 - 12/2013
2	Liver X ReceptorsIBA 01/2015 - 09/2008
2	LDL Receptors (LDL Receptor)IBA 01/2015 - 10/2011
2	oxidized low density lipoproteinIBA 01/2013 - 05/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 09/2008
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2012 - 03/2003
1	Sorafenib (BAY 43-9006)FDA Link 03/2022
1	mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	MannosidasesIBA 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	Purinergic P2X7 ReceptorsIBA 01/2020
1	Dietary Fats (Dietary Fat)IBA 03/2019
1	Oleic Acid (Oleate)IBA 12/2018
1	src-Family KinasesIBA 12/2018
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2018
1	ThrombospondinsIBA 12/2017
1	Phospholipids (Phosphatides)FDA LinkGeneric 12/2017
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	Atorvastatin (Lipitor)FDA Link 01/2016
1	Malondialdehyde (Propanedial)IBA 01/2016
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2015
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2015
1	Oxidoreductases (Dehydrogenase)IBA 01/2015
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 01/2015
1	PalmitatesIBA 04/2014
1	Blood Glucose (Blood Sugar)IBA 12/2013
1	Proteins (Proteins, Gene)FDA Link 05/2012
1	Bile Acids and Salts (Bile Acids)IBA 05/2012
1	Serine (L-Serine)FDA Link 04/2012
1	Lipase (Acid Lipase)FDA Link 06/2011
1	Sterol Esterase (Hormone-Sensitive Lipase)IBA 06/2011
1	Lipoprotein Receptors (Lipoprotein Receptor)IBA 12/2009
1	ATP Binding Cassette Transporter 1IBA 12/2009
1	Interleukin-1beta (Interleukin 1 beta)IBA 09/2008
1	PPAR alphaIBA 09/2008
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2007
1	Biological ProductsIBA 09/2007
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 12/2005

Therapy/Procedure

1	Transplantation 10/2007